Potential therapeutic peptides targeted to adiponectin receptors, able to modulate the AMPK pathway and regulate the glucose and lipid metabolism

Often associated with metabolic syndrome, type 2 diabetes is increasingly linked to obesity. By binding to its receptors (AdipoR1 and AdipoR2), adiponectin activates a key enzyme in cellular homeostasis, the 5' adenosine monophosphate-activated protein kinase (AMPK). Adiponectin and the AMPK pathway play an important role in the regulation of both glycaemia and lipid metabolism, representing thus a promising tool for the treatment of diabetic and obese patients. Our goal was to develop a therapeutic agent capable of specifically binding the adiponectin receptors and modulate the signaling pathways involved in gl…