Analysis of transcriptomic changes during cold ischaemia in time-zero biopsies of liver allografts

Background: Liver transplantation remains the only treatment option for many patients with end-stage liver disease or acute liver failure. Despite substantial progress in preventing graft failure over the past decades, a substantial number of patents still suffer from progressive graft dysfunction, subsequently leading to re-transplantation or death. Thus identifying the molecular causes of graft failure would certainly be a major step ahead in organ preservation and patient survival. Cold ischemia time appears to be a good predictor among the factors influencing patient and graft survival. Meta-analysis have re…