Uncovering the role of lysyl oxidase-like 2 (LOXL2) in rhabdomyosarcoma

Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence that originates as a consequence of regulatory disruption in the growth and differentiation of muscle precursor cells. Previous results of our group deciphered the epigenetic profiling of RMS, compared to healthy tissue, revealing the hypomethylation of a potential enhancer of LOXL2. LOXL2 is an amine oxidase that catalyzes the covalent crosslinking of collagen and elastin in the extracellular matrix. Apart from its traditional role, novel functions have been attributed to LOXL2 related to tumor progressio…