The MCM complex is a critical node in the miR-183 signaling network of MYCN-amplified neuroblastoma cells
M Lodrini, G Poschmann, V Schmidt, J Wünschel, D Dreidax, O Witt, T Höfer, HE Meyer, K Stühler, A Eggert, HE Deubzer · Klinische Pädiatrie · 2016 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: MYCN and HDAC2 jointly repress the transcription of tumor suppressive miR-183 in neuroblastoma. Enforced miR-183 expression induces neuroblastoma cell death and inhibits xenograft growth in mice. Methods: Here we aimed to focus more closely on the miR-183 signaling network using a label-free mass spectrometric approach. Results: Analysis of neuroblastoma cells transfected with either control or miR-183 expression vectors identified 85 differentially expressed proteins. All six members of the minichromosome maintenance (MCM) complex, which is indispensable for initiation and elongation during DNA re…
