Enteroscopy with a confocal laser endomicroscope detects early changes related to acute gastrointestinal graft-versus-host disease in the jejunum – A prospective study involving 2…

Introduction: Graft-versus-host disease (GvHD) is a major cause of morbidity and mortality in patients after allogeneic hematopoietic stem cell transplantation (HSCT). Confocal laser endomicroscopy (CLE) provides in-vivo histology of gastrointestinal pathology and has recently been investigated for diagnosing acute GvHD of the colon. Aims and Methods: This prospective study aimed to evaluate GvHD-associated changes in the upper GI tract (including the proximal jejunum) by CLE. Consecutive patients with clinical suspect of acute gastrointestinal GvHD after HSCT underwent upper GI enteroscopy with an endoscope-bas…