Eukaryotic Translation Initiation Factors are overexpressed in Colorectal Carcinoma compared to Normal Colorectal Mucosa: eIFs might serve either as prognostic or predictive bioma…
N Golob-Schwarzl, C Schweiger, C Koller, M Gogg-Kamerer, C Lackner, J Haybaeck, S Uranitsch, A Punschart, P Stiegler, M Keil, J Hoffmann, D Henderson, H Lehrach, C Reinhard, S Lax · Zeitschrift für Gastroenterologie · 2016 · Heft 05
Bibliografische Angaben
Zusammenfassung
Objective: Colorectal cancer (CRC) is the third most common cause of cancer related death and the third most frequently diagnosed cancer entity worldwide with more than one million new cases each year. Some eukaryotic translation initiation factors (eIFs) are increased in CRC compared to precursor lesions and normal mucosa. eIFs are involved in the regulation of protein synthesis and functionally linked to the MAPK and the mTOR signaling pathways, which have become major targets for cancer therapy. Methods: Basic expression profiling of paired CRC, non-neoplastic colorectal mucosa (NNCRM), CRC liver metastases a…
