The role of prophylactic treatment with A. muciniphila in the acute alcoholic liver disease

Introduction: Alcoholic liver disease (ALD) is a major cause for liver related deaths. ALD includes a clinical spectrum ranging from steatosis over alcoholic steatohepatitis (ASH) to liver fibrosis and hepatocellular carcinoma (HCC). Alcohol induces intestinal bacterial overgrowth and dysbiosis, these conditions are moreover associated with increased levels of lipopolysaccharides (LPS) and an altered gut barrier. Direct toxic impact of ethanol on the hepatocyte and translocation of LPS from the gut into the liver, play an important role in the pathogenesis of ALD. It was shown for A. muciniphila, a commensal bac…