Transferrin-Polyethylenimine Nanoparticles for T Cell Targeted siRNA Delivery as Novel Anti-inflammatory Asthma Therapy

Since asthma is a major public health problem affecting 235 million people worldwide and in a considerable section of patients the disease is still not controlled in a satisfactory way, novel efficient anti-inflammatory therapies with minimum side-effects are urgently needed. The disorder is characterized by chronic inflammation of the airways caused by infiltration of immune cells including T helper 2 (Th2) cells, a type of activated T cells (ATC), in the lung. Downregulation of genes associated with Th2 cytokines, and especially respective transcription factors such as GATA3, is a promising approach to early-o…