Genetic Determinants of Inflammation in Sarcoidosis

Sarcoidosis is a multi-systemic granulomatous disorder of unknown aetiology. Most of the known or suspected genes involved in sarcoidosis play a role in an inflammatory response to an antigenic challenge, with predisposing genes mainly involved in T cell and macrophage function and antigen presentation and recognition. New data will be presented using common variant polygenic risk scores that demonstrates the underlying genetic relationship of sarcoidosis to other complex inflammatory disorders. The potential role of new candidate genes discovered from whole genome association and admixture mapping approaches, s…