OEIS complex – associated malformations in 12 new cases

Purpose: The OEIS (omphalocele, exstrophy, imperforate anus, and spinal defects) complex is a rare variant of the bladder exstrophy epispadias complex with in most cases unknown etiology. Due to the rarity of the disease no large series that describe the prenatal spectrum of disease or additional malformations exist. Material and methods: In this study we present the prenatal findings in a series of 12 cases from 2004 to 2013. Results: All fetuses showed exstrophy of the bladder, 9/12 an omphalocele, 9/12 anal atresia, 10/12 showed neural tube defects, 4/12 vertebral defects, 5/12 lower extremity defects includi…