Incidence of germline mutations in risk genes including BRCA1/2 in consecutive ovarian cancer (OC) patients (AGO TR-1)
S Kommoss, P Harter, J Hauke, F Heitz, A Reuss, F Marmé, A Heimbach, K Prieske, L Richters, A Burges, G Neidhardt, N de Gregorio, A El-Balat, F Hilpert, W Meier, M Heubner, K Kast, I Braicu, E Hahnen, R Schmutzler · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background: Identification of families at risk for OC including recommendation for prophylactic surgery is the only effective method to reduce OC mortality. In addition, BRCA1/2 mutations are known as prognostic factor and target for treatment. Methods: Prospective counseling and testing of consecutive patients with first diagnosis or platinum sensitive relapse of invasive epithelial OC. Testing of 25 risk genes related to ovarian cancer. A positive mutation was defined as class 4/5 mutation and a positive family history was defined as at least one relative with breast cancer (BC) or OC or BC in personal history…
