Higher pregnancy rate of embryos with synchronous transition from the 2-cell to the 4-cell stage independently of the GnRH analogue used for controlled ovarian stimulation

Objectives: To validate different morphokinetic parameters of early human embryonic development in vitro as predictors for the developmental potential of human embryos. To this end we compared pregnant and non-pregnant patients following controlled ovarian stimulation (COS) with two types of GnRH analogue and intracytoplasmic sperm injection (ICSI). Study design: In a retrospective observational study we analysed different morphokinetic parameters of 432 embryos cultured in the EmbryoScopeTM time-lapse monitoring system (TMS) from 217 patients (from 25 to 45 years of age) undergoing a fresh cycle of oocyte retri…