Expression profiling of Thyroid-Hormone-Receptor alpha isoforms in breast cancer

Introduction: Both Thyroid-Hormone-Receptor alpha (TRα) 1 and 2 are processed from a gene named THRA by alternative splicing. While TRα1 holds oncogenic activity, TRα2 is suspected to act as a repressor of transcription thereby potentially antagonizing TRα1 signalling. Whether an immune-profiling of breast cancer (BC) taking into account both receptors may be of prognostic interest, remains to be unknown. Materials: A cohort of 266 BC patients was studied. Methods: TRα1 and TRα2 were detected in BC tissue (n = 266) by immunohistochemistry and correlated to clinico-pathological parameters. Results: TRα1 and TRα2…