Head-to-head comparison of the impact of Aurora A, Aurora B, Repp86, CDK1, CDK2 and Ki67 expression in 2 of the most relevant gynaecological tumor entities

Purpose: The deregulation of cell cycle kinases plays a crucial role in carcinogenesis and the expression of various kinases has been attributed to aggressive tumor growth and unfavourable prognoses in oncological patients. We therefore aimed to evaluate the expression of Ki67 among 5 additional cell cycle kinases in mammary and ovarian tumor specimens and to find a correlation with clinicopathological parameters. Methods: 76 mammary and 93 ovarian benign and malignant tumor samples were immunohistochemically stained and evaluated for the expression of Aurora A and B, Repp86, CDK1 and 2 (only breast specimens) a…