CareLit Fachartikel
Uptake and Distribution of the Estramustine-Phosphate Metabolite Estramustine after Single-Dose Injection in Patients with Prostatic Cancer
P. H. Walz, P. Björk, K. Edman, P. O. Gunnarsson, B. Hartley-Asp · Aktuelle Urologie · 1996 · Heft S 1 · S. 92-93
Dokument
1067922
CareLit-ID
Jahr
1996
Publikation
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Metadaten
DOI
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Zusammenfassung
Summary: The concentration of estramustine (EaM) in serum and tumor tissue of 19 patients with prostatic carcinoma was determined after single i. v. injection of estramustine phosphate (300 or 600 mg) administered 12 to 15.5 hours prior to radical prostatectomy. The concentration (mean ± SD) was 21.9 ± 10.3 ng/ml in serum and 234 ± 168 ng/g in the tumor tissue. In patients treated with 300 mg the tumor tissue: serum ratio was decreased (12.0: 1 for 600 mg and 5.4: 1 for 300 mg, respectively). EMBP was detected in 18/19 (95 %) of the specimens, levels were positively correlated both with the tumor: serum ratio (r…
Schlagworte
Prostatic cancer
Estramustine distribution
Estramustine binding protein
Tumor
After
Aktuelle Urologie
