Successful treatment of CINCA syndrome with a combination of etanercept and methotrexate in a Greek child

A 15 years old girl of Greek descent was admitted to our hospital for experimental treatment. The patient had been previously treated within the first 3 years of her life with azathioprine and ASS due to a diagnosis of Still's disease. At age 7 years CINCA syndrome (CINCA stands for Chronic Infantile Neurological Cutaneous and Articular) was suspected. In the following years different immunosuppressive therapy approaches were performed, none of which led to remission of the disease. Before admission to our hospital in May 2003, the patient suffered continuously from arthralgia, urticaria, as well as recurrent ep…