Increased Leiden mutation and decreased serum levels of vitamin A and zeaxantin in patients with oesophageal, gastric, liver, pancreatic and colorectal cancers

Backgrounds: The increased prevalence of Leiden mutation (replacement of Arg by Glu of residue 506 in the factor V molecule, FVR, 506 Q) and the decrease serum levels of retinoids (vitamin A, zeaxantin, lutein, α- and ß-carotene) have been proven in the patients in chronic bowel inflammatory diseases and colon polyposis (Mózsik et. al.: J. Physiol (Paris). 95: 488–494, 2001). Aim: was to study of changes in Leiden mutation and in serum levels of vitamin A and α- and ß-carotene (α- and ß-cryptoxantin, zeaxantin) inpatients with oesophageal (n=8), gastric (n=21), hepatocellular (n=15), pancreatic (n=10), and color…