Detection of signal transduction molecular targets in gastrointestinal tumours
F Pintér, L Berta, K Diófalvi, T Micsik, E Schäfer, T Gyökeres, J Hamvas, M Tejeda, G Varga, I Peták, S Paku, R Schwab, Á Pap · Zeitschrift für Gastroenterologie · 2004 · Heft 05
Bibliografische Angaben
Zusammenfassung
Detection of molecular genetic alterations is a crucial requirement for personalized treatment approaches. Aims: Establishment of parallel morphological methods to detect expression of signal transduction (ST) molecular targets of the EGF receptor family for personalized therapy. Materials and methods: 50 rectum or sigma adenocarcinomas were stained by immuno-histochemistry (IHC) to evaluate the relationship between expression of EGFR molecule members and 5 year survival. Erb family was taken as possible therapeutic target. We examined the expression of EGFR and HER-2 molecules in gastrointestinal and breast car…
