Immunohistochemical analysis of the different neuropeptide containing nerve fibres and immunocompetent cells in the gastritis

Background aims: Changes of the density of different neuropeptide-containing nerve fibres might be important in the different diseases. Therefore our aim was to investigate the precise localization and distribution of the different immunoreactive (IR) nerve fibres in the mucosa of the stomach and compare with the data from the biopsy of patients with gastritis. Methods: Vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), substance P (SP), nitric oxide synthase (NOS) and tyrosine β-hydroxylase (TH) IR nerve elements and poly(ADP-ribose) polymerase (indicator of PARP activation) IR connective tissue cel…