Neurofibromatosis, cutan melanoma and hyper-thyroidism in a HCV positive patient treated with interferon

Introduction: Development of malignant melanoma in neurofibromatosis is rare, but the association of these two disorders seems reasonable in theory, as both are abnormalities of a neural crest origin. Case report: A 43-year-old woman had been managed with neurofibromatosis (NF-1) for 16 years, when she presented increased serum gamma-glutamyltransferase and serum alkaline phosphatase activity at regular check-up. Anti-HCV antibody positivity was detected. Physical investigation revealed an expanding pigmented lesion on her back histologically proved to be cutan melanoma. Interferon treatment was applied, which i…