CareLit Fachartikel

Pan-Caspase Inhibition Attenuates Hepatic Injury, Inflammation and Fibrosis in the Bile Duct Ligated Mouse

A Canbay, A Kahraman, S Bronk, G Gerken, G Gores · Zeitschrift für Gastroenterologie · 2004 · Heft 08

Dokument
1070932
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Canbay, A Kahraman, S Bronk, G Gerken, G Gores
Ausgabe
Heft 08 / 2004
Seiten
–
Erschienen: 2004-08-18 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2004-831776

Zusammenfassung

Hepatocyte apoptosis promotes hepatic injury and fibrosis whereas activated stellate cell (HSC) apoptosis limits hepatic fibrosis. Therefore it is unclear whether phamacologic inhibition of apoptosis whould attenuate liver injury or promote hepatic fibrosis. Thus, our AIM was ascertain the net effect of inhibiting liver cell apoptosis on liver injury, inflammation and hepatic fibrogenesis. Methods: The effect of a pan-caspase inhibition IDN–6556 on these parameters in the 3-day bile duct ligated (BDL) mouse was examined. Hepatocyte apoptosis was assessed by the TUNEL assay and immunofluorescence for active caspa…

Schlagworte

Apoptosis IDN-6556 Fibrosis Inflammation Real-Time PCR Zeitschrift für Gastroenterologie