Functional MRI Activation Pattern in Runs of Focal and Generalized Spike Wave Discharges

Using fMRI correlated with simultaneous and continuous registration of electroencephalography (EEG/fMRI), we analyzed regional changes in blood oxygen level-dependent (BOLD) activity in association with spontaneous focal interictal spikes and generalized spike and waves in two epileptic patients. Patient 1 had newly diagnosed symptomatic focal seizures caused by an astrocytoma WHO Grade II in the right frontal lobe and the right thalamus. Patient 2 suffered from idiopathic generalized epilepsy with frequent absence seizures (GWSD). A 32-channel MR-compatible EEG was recorded continuously inside a 3 T MR scanner.…