Deficits in Executive Control Function in Parkinson's Disease with Dementia Compared to Alzheimer's Disease and Parkinson's Disease without Dementia

Objective: Besides motor deficits, patients with Parkinson's disease can suffer from cognitive and attentional decline, particularly from a lack of executive control functions. This specific problem was analyzed in view of the motor and cognitive symptomatology occurring in this condition. Method: Target detection, response inhibition and response switching were tested in outpatients with Parkinson's disease with dementia (PDD, n=9), Parkinson's disease without dementia (PD, n=13), Alzheimer's disease (AD, n=3) and controls (CO, n=9), using a visual Go/NoGo paradigm. PDD and AD were matched for level of Mini-Men…