Measurement of Transcallosal Inhibition in Early Relapsing-Remitting Multiple Sclerosis

Early diagnosis of relapsing-remitting multiple sclerosis (RR-MS) is important to start immunmodulatory prophylaxis at an early stage in the course of the disease. According to the McDonald criteria [1], magnetic resonance imaging (MRI) is fundamental in detecting spatial and temporal dissemination. An evidenced-based review of the usefulness of evoked potentials in making the diagnosis of RR-MS did not test motor evoked potentials (MEP) [2]. We investigated whether the analysis of transcallosal inhibition (TI) using transcranial magnetic stimulation (TMS) is useful for the early diagnosis of RR-MS. 12 patients…