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Latent transforming growth factor-β binding protein 1 (LTBP1) – only one representative of various related proteins involved in the development of liver fibrosis?

F Drews, M Moser, AM Gressner, R Weiskirchen · Zeitschrift für Gastroenterologie · 2005 · Heft 01

Dokument
1071415
CareLit-ID
Jahr
2005
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
F Drews, M Moser, AM Gressner, R Weiskirchen
Ausgabe
Heft 01 / 2005
Seiten
–
Erschienen: 2005-01-14 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2005-861586

Zusammenfassung

Latent transforming growth factor-β binding proteins (LTBP) forms a subfamily of the extracellular proteins fibrillin 1 and fibrillin 2 which constitute the backbone of extracellular filaments. Common features of the highly conserved LTBP structure are the pattern of eight cysteine residues and epidermal growth factor (EGF)-like repeats. LTBP are known to be important for the folding and secretion of TGF-β, localization to the ECM and also activation process of TGF-β particularly during liver fibrosis. While different stages of these processes are still unknown further investigations concerning the molecular mec…

Schlagworte

ECM LTBP TGF-β alternative splicing liver fibrosis Zeitschrift für Gastroenterologie