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Identification of the N-Acetylcysteine Sensitive Receptor Endoglin in Hepatic Stellate Cells

S Meurer, L Tihaa, B Lahme, AM Gressner, R Weiskirchen · Zeitschrift für Gastroenterologie · 2005 · Heft 01

Dokument
1071416
CareLit-ID
Jahr
2005
Publikation
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DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
S Meurer, L Tihaa, B Lahme, AM Gressner, R Weiskirchen
Ausgabe
Heft 01 / 2005
Seiten
–
Erschienen: 2005-01-14 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2005-861596

Zusammenfassung

Introduction: TGF-β is the major cytokine regulating hepatic stellate cell (HSC) function in the course of liver fibrogenesis. In a previous study we could show that the reducing substance N-Acetylcysteine (NAC) is able to block TGF-β signalling in HSC by different means than modification of the cellular redox state. Analyzing the TGF-β receptor proteins ALK5 (type I receptor), RII (type II receptor) and betaglycan (type III receptor) with receptor specific antibodies revealed no differences between treated and untreated cells. In contrast, using an antibody (sc–6199), which recognizes both type III receptors, b…

Schlagworte

Fibrose N-Acetylcysteine TGF-β TGF-β receptor endoglin signalling Zeitschrift für Gastroenterologie