CareLit Fachartikel
A pilot study of fenofibrate in hyperlipidemic pts with nonalcoholic fatty liver disease (NAFLD)
I Nagy, T Korom, A Pálvölgyi, J Lonovics · Zeitschrift für Gastroenterologie · 2005 · Heft 05
Dokument
1071823
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Jahr
2005
Publikation
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Metadaten
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Zusammenfassung
Background and aim. Obese pts with metabolic syndrome often have hypertriglyceridemia and NAFLD. Beside of its lipid-lowering effect, fenofibrate may reduce the circulating level of TNF-α, a cytokine incriminated as playing a role in the development of insulin resistance and NAFLD. We therefore conducted a 6-month pilot study to assess the efficacy of fenofibrate among NAFLD pts. Methods. Ten obese, hyperlipidemic pts (6 men and 4 women) with biopsy-proven NAFLD were enrolled. All had a body mass index (BMI) of >30kg/m2 and displayed a pathologically elevated serum ALT level. Micronized fenofibrate (200mg once d…
Schlagworte
Cholesterol
Cytokine
Obesity
Biopsy
Diet
Zeitschrift für Gastroenterologie
