Mucosal expression of Toll-like receptors (TLR2, TLR3 and TLR4) in children with coeliac disease
B Szebeni, G Veres, A Dezsőfi, Á Vannay, K Rusai, L Szőnyi, B Vásárhelyi, A Arató · Zeitschrift für Gastroenterologie · 2005 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background and aim: Besides the central role of the adaptive immunity, innate immune responses also play an important role in the development of coeliac disease. Recently it has been found that rod-shaped bacteria are frequently associated with the mucosa of coeliac disease patients but not with controls. Bacterial products are recognized by pattern recognition receptors (PRRs) like Toll-like receptors (TLRs), which are key regulators of the innate immune system. After ligand binding these receptors trigger the release of proinflammatory or chemotactic cytokines and chemokines, thus lowering the thereshold for t…
