CareLit Fachartikel
Imaging the impact of deep brain stimulation on transmitter activity and energy metabolism of basal ganglia networks in advanced Parkinson's disease
R Hilker, L Burghaus, A.H Jacobs, W.D Heiss · Aktuelle Neurologie · 2005 · Heft 10
Dokument
1072124
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Jahr
2005
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Zusammenfassung
Functional brain imaging with PET provides a sensitive tool for detecting effects of medical and surgical therapies in patients with Parkinson's disease (PD) by means of metabolism, blood flow and receptor binding. Therefore, monitoring of the pathophysiological basis of effective treatment strategies and their possible impact on neuronal networks and on PD progression becomes available. PET measurements with the reversible dopamine-D2/3-receptorligand 11C-racloprid in the stimulator on- and off-condition showed that the strong antiparkinsonian effect of STN-DBS is independent from alterations of endogenous dopa…
Schlagworte
Basal Ganglia
18FDG
Movement
Blood
After
Aktuelle Neurologie
