Differences in Foxp3+ regulatory T cells in patients with intestinal graft-versus-host (GvH) disease, inflammatory bowel disease and infectious diseases
C Loddenkemper, K Rieger, T Fietz, E Berg, H Terpe, D Wolff, S Miehlke, M Bornhäuser, T Schneider, T Schneider, J Maul, M Zeitz, H Stein, E Thiel, L Uharek, R Duchmann · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Objectives: The clinical diagnosis of intestinal GvHD is often complicated, even if bioptical material is present. So far, it is difficult to separate between GvHD and infectious complications, since distinguishing immunological features are not established. In a multicenter study, we quantified Foxp3+ immunoregulatory T cells (Treg) and effector T cells in the intestinal mucosa of patients with (A) GvHD, (B) IBD and (C) infectious diseases of the gut. Methods: 95 paraffin-embedded tissue samples (62 with GvHD and 33 without histological GvHD) derived from intestinal biopsies from 49 patients undergoing allogene…
