CareLit Fachartikel
HIF–1alpha regulates the bactericidal capacity of phagocytes
T Cramer, B Wiedenmann, M Höcker · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Dokument
1072189
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Myeloid cells, i.e. monocytes/macrophages and polymorphnuclear neutrophils (PMN) are of pivotal importance for the body’s ability to defend itself against invading microorganisms. The main arenas of myeloid cell function, e.g. abscesses, inflamed tissues and wounds, are characterized by hypoxic conditions. This suggests a pronounced dependence of macrophages and PMN on the hypoxia-inducible. Here, we demonstrate that the principle mediator of cellular adaptation to low oxygen levels, the transcription factor HIF–1alpha, is essential for bactericidal activity of myeloid cells. Functional inactivation of HIF–1a in…
Schlagworte
Bacterial Infections
Bacteria
Allele
Blood
Tumor
Zeitschrift für Gastroenterologie
