Liver sinusoidal endothelial cells promote the transendothelial migration of T-cells in response to chemokines by different surface presentation

Studies on T-cells in the liver provide evidence both intravascular trapping and traffic into and exit from the parenchyma, implying active transendothelial migration. In the present study we demonstrate that liver sinusoidal endothelial cells support transmigration of T-cells more efficiently than other endothelial cells. The transendothelial migration of T-cells was slightly higher in case of spontaneous migration and greatly enhanced in response to CXCL12 and CXCL9, two chemokines that are constitutively expressed within the liver. The differential migration of subsets of T-cells towards chemokines was not al…