Functional Mapping of Hepatitis C Virus Envelope-Heparan Sulfate Interaction
H Barth, B Gissler, EM Munoz, F Zhang, RJ Linhardt, E Depla, G Maertens, P Maurel, B Boson, FL Cosset, HE Blum, TF Baumert · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Hepatitis C virus (HCV) is a major cause of chronic hepatitis world-wide. Although a detailed analysis of its genomic organization has led to the identification of various genetic elements, knowledge of receptor-mediated viral attachment and entry is still limited. Glycosaminoglycan (GAG) chains on cell surface proteoglycans provide initial docking sites for the binding of viruses to target cells. Recently, we have shown that cellular binding of HCV envelope glycoprotein E2 requires heparan sulfate (HS) (Barth et al. 2003, J. Biol. Chem. 278: 41003). In this study, we aimed to (i) assess the role of E1 for viral…
