The peripheral benzodiazepine receptor: Clinical importance of up-regulation during human colorectal carcinogenesis and tumor spread
P Grabowski, K Maaser, Y Oezdem, A Krahn, B Heine, H Stein, HJ Buhr, M Zeitz, H Scherübl · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Aims: The peripheral benzodiazepine receptor (PBR) is overexpressed in a variety of cancers. In UICC III colorectal cancers, a high level of PBR overexpression correlates with poor prognosis. However, little is known about the role of PBR in the development and progression of colorectal cancer. This study addresses the up-regulation of PBR during colorectal carcinogenesis and tumor spread. Methods: 116 consecutive patients undergoing surgery for colorectal cancer with either regional (59 patients) or distant metastases (57 patients) were followed-up for five years or until death. 24 of the 59 patients with initi…
