COX-2 and HER-2/neu but not steroid hormone receptors represent therapeutic target molecules in Paget's disease of the vulva and breast

Purpose: Paget disease (PD) of the vulva and breast is rare lesion and occurs for about 1% of patients with malignant disease at these localisations. Some lesions are multifocal and recur for about 30% at the vulva and might cause recurrency after breast conserving therapy in breast cancer. Evaluating therapeutic relevant molecules PDs were investigated immunohistochemically. Methods: Eight vulvar and 11 breast PDs were stained with antibodies against estrogen and progesterone receptors, HER-2/neu (Hercept-Test) and COX-2 with semiquantitative evaluation of the staining results. Results: All tested vulvar and 2/…