PAI-1 as a prognistic relevant parameter of the tumorassociated proteolysis in cervical carcinoma

Purpose: The expression of uPA and PAI-1 as parameters of tumor-associated proteolysis has been implicated in the process of tumor cell invasion and metastatic process. But, there are limited information of the impact of these parameters in cervical carcinoma (CX). Methods: Quantitative levels for uPA (n=114) and PAI-1 (n=103) were searched in operative treated, surgially staged squamous cell cancer of the uterine cervix, using ELISA-technique. Results were tested regarding their impact in predicting pelvic lymph nodes metastases, tumor recurrency and recurrence free survival (RFS) using uni- and multivariate an…