CareLit Fachartikel

TGF-β induced upregulation of CRP2 and SRF in activated hepatic stellate cells–Involvement in smooth muscle gene expression during liver fibrogenesis?

J Herrmann, U Haas, E Van de Leur, A Gressner, R Weiskirchen · Zeitschrift für Gastroenterologie · 2006 · Heft 01

Dokument
1072521
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
J Herrmann, U Haas, E Van de Leur, A Gressner, R Weiskirchen
Ausgabe
Heft 01 / 2006
Seiten
–
Erschienen: 2006-01-16 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2006-931646

Zusammenfassung

Introduction: Activation of hepatic stellate cells (HSC), mainly triggert by transforming growth factor-β (TGF-β), is a key event in liver fibrogenesis accompanied by modulations of gene expression e.g. upregulation of contractile proteins known as markers of smooth muscle cell (SMC) differentiation. In SMCs the marker genes are principally regulated by binding of serum response factor (SRF) to unique sequences in their promoters, called CArG-boxes. In early chick embryonic cardiovascular development a functional co-association between SRF and the potent SMC marker cystein- and glycine-rich protein 2 (CRP2) was…

Schlagworte

CRP2 Fibrosis HSC SRF TGF-beta gene regulation Zeitschrift für Gastroenterologie