CareLit Fachartikel
Hepatocellular neoplasms induced by low-number pancreatic islet transplants in autoimmune diabetic BB/Pfd rats
F Dombrowski, C Mathieu, M Evert · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Dokument
1072524
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Jahr
2006
Publikation
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Zusammenfassung
It has previously been shown that combined high local hyperinsulinism and hyperglycemia after low-number islet transplantation into the livers of streptozotocin-diabetic rats lead to the development hepatocellular neoplasms but a substantial co-carcinogenic effect of genotoxic streptozotocin could not be ruled out completely. Thus, we herein investigated this model in BB/Pfd rats (n=805; 9 experimental groups), which develop spontaneous auto-immune diabetes similar to human type 1 diabetes. After low-number islet transplantation (n=450), the liver acini downstream of the islets show insulin-induced alterations:…
Schlagworte
hepatocarcinogenesis
hepatocellular carcinoma
insulin
islet transplantation
preneoplasia
Zeitschrift für Gastroenterologie
