Improvement of Plasma Amino Acids During Fractionated Plasma Separation and Adsorption (Prometheus®)

Introduction: Prometheus® is a newly designed extracorporeal system for treatment of patients with liver failure. It consists of a polysulfon plasmafilter for serum albumin separation and resin adsorbers in a secondary circuit for direct toxin adsorption (FPSA; fractionated plasma separation and adsorption). In addition, high-flux hemodialysis is performed. We prospectively evaluated the course of plasma amino acids during Prometheus®. Methods: We studied 9 patients with acute-on-chronic liver failure and concomitant renal failure. A single session of Prometheus® therapy was performed for 4 hours in all patients…