Synthesis and in vivo testing of a bimodal nanoparticle combining detectability in MRI and PET-Imaging
L Stelter, J Pinkernelle, F Neumann, R Michel, H Amthauer, R Felix, A Jordan, U Teichgräber · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2006 · Heft 03
Bibliografische Angaben
Zusammenfassung
Purpose: Combining the high spatial and temporal resolution of Magnetic Resonance Imaging (MRI) with the outstanding sensitivity of Positron Emission Tomography (PET) provides a powerful tool for molecular and cellular imaging. Methods: A aminosilan-coated nanoparticle (MagForce®) was covalently linked with the positron-emitting radionuclide Gallium-68. These particles were injected intravenously into healthy Wistar rats (n=5). PET-imaging was performed directly p.i. using a small-bore Animal-PET. A dynamic series (6×5min.) was performed combined with a emission study of 30 minutes. The same animal underwent 1.5…
