Role of Phosphodiesterases in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease with a fatal outcome. The underlying causes of IPF are currently unknown and there is no available drug therapy that effectively blocks or reverses the progressive scarring of the lung. Drugs which interfere with the cyclic nucleotide levels have profound effects on regulation of airway smooth muscle tone, activation of inflammatory cells, epithelial and smooth muscle cell apoptosis, platelet aggregation, fluid homeostasis. In the present study, we thus intend to investigate the role of the cyclic nucleotide phosphodiesterases…