Acute lung injury induced by the pyrrolizidine alkaloid monocrotaline in mice
R Dumitrascu, S Köbrich, H Traupe, E Dony, S Pullamsetti, R Savai, A Samidurai, N Weissmann, A Ghofrani, F Grimminger, W Seeger, R Schermuly · Pneumologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common and lethal conditions. The mortality rate of ALI/ARDS depends on the underlying cause, varying from 60% for sepsis-induced ALI/ARDS. The aim of this study was to develop an animal model of ALI in mice employing monocrotaline (MCT). The MCT induces endothelial injury and pulmonary hypertension in rats. The proposed mechanism of action includes activation of MCT by the liver to the putative electrophile monocrotaline pyrrole (MCTP), which causes endothelial injury in the pulmonary vasculature with subsequent remodeling of the precapi…
