Localisation of Epileptic Foci in Children with Focal Epilepsies using 3-Tesla Simultaneous EEG-fMRI Recordings

Objective: EEG-related fMRI (EEG-fMRI) allows to detect focal epileptic brain activity by measuring spike related BOLD responses. Several studies focussed on the localization of the irritative network in adult epilepsy patients [1], but fMRI knowledge on the developing brain is lacking. This study applied the EEG-fMRI technique to the pediatric age group and evaluated possible clinical implications. Fig. 1A Fig. 1B Methods: Nine children (age: 11.6±3.6 years, with idiopathic (3), symptomatic (3) and cryptogenic (3) epilepsy) were investigated under sedation using simultaneous recordings of EEG (Brain Vision, MR-…