Experimental evaluation of biomarkers to predict local tumor control after fractionated radiotherapy in human Squamous Cell Carcinomas (hSCC)

Introduction: For the further development of biological imaging for radiotherapy it is crucial that marker development focuses on parameters that are relevant for local tumor control after fractionated irradiation. Outcome after fractionated irradiation is determined by a complex of different factors which can be summarized as the 5 R's of fractionated radiotherapy, i.e. repopulation, reoxygenation, recovery from sublethal damage, redistribution and intrinsic radiation sensitivity. Material and Methods: Different biomarkers reflecting these factors, such as proliferation, or hypoxia have been studied in a panel…