Noradreneline deficiency aggrevates learning and memory impairment independent of Aß Levels in APPPS1 mice

Locus coeruleus (LC) degeneration and subsequent noradrenaline (NA) deficiency occur early in Alzheimers disease (AD) and may siginificantly precede amyloid-ß plaque and neurofibrillary tangle formation. The LC projects to areas that are affected in AD, including the hippocampus and enthorhinal cortex. While it is known that NA physiologically modulates long term potentiation (LTP), a cellular correlate of learning and memory, in the hippocampus, the consequences of LC degeneration on learning and memory are less clear. In the present study we used the APP/PS1 transgenic model an established model of AD, to test…