Impairments of postural control in patient's with Huntington's disease while sitting – a new motor phenotype biomarker?

Background: Patients with Huntington's Disease (HD) develop a progressive impairment of stability of stance and walking (Rumpf et al. 2007 [abstract]), frequently resulting in falls and injuries. Objective assessment of postural control in HD may be helpful to assess the risk of injury and may serve as a surrogate for motor phenotype dysfunction. Objective: To investigate whether patients with HD (1) exhibit impairments in the control of postural stability while sitting with or without availability of visual feedback (2) assess whether these measures correlate to the severity of disease as assessed clinically by…