CareLit Fachartikel
Inhibin-alpha subunit is an independent prognostic parameter in human endometrial carcinomas
I Mylonas, S Worbs, N Shabani, D Dian, U Jeschke, K Friese · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Dokument
1073034
CareLit-ID
Jahr
2008
Publikation
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Inhibins are dimeric glycoproteins, composed of an alpha-subunit (inhibin-a) and one of two possible beta-subunits (bA or bB), with substantial roles in human reproduction and in endocrine-responsive tumours. Aims of this study were to determine the distribution of inhibin-a, -bA and -bB in malignant human endometrial tissue and the assessment of an association with specific clinicopathologic tumour features and clinical outcome. A series of 302 endometrial cancer tissue samples were immunohistochemically analysed with monoclonal antibodies against inhibin-subunits. The inhibin-a subunit showed a significant ass…
Schlagworte
cancer
endometrium
immunohistochemistry
inhibin-betaB
inhibin-alpha
inhibin-betaA
prognosis
survival
Geburtshilfe und Frauenheilkunde
