Importance of the Renin-Angiotensin-System in human granulosa lutein cells – RAS in granulosa cells

The Renin-Angiotensin system (RAS) has been suspected not only to influence the vascular tone but also to regulate angiogenesis. It was shown that Angiotensin II influences angiogenic factors such as vascular endothelial growth factor (VEGF). The most intense physiologic angiogenesis in adults occurs in luteal formation, which is further increased under human chorion gonadotropin (hCG). Recently, the presence of the RAS has been reported in the human corpus luteum. Since VEGF is regulated by hCG in the corpus luteum and since VEGF has also been shown to be regulated by Angiotensin II, we hypothesised that Angiot…