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Alternative splicing of human CYR61 (CCN1) originates from intron retention and splicing pattern is altered by hypoxia

M Hirschfeld, M Jäger, E Stickeler · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09

Dokument
1073043
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
M Hirschfeld, M Jäger, E Stickeler
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-12 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0028-1088706

Zusammenfassung

Background and aims: Alternative pre-mRNA splicing is a regulatory mechanism of gene expression to generate different protein isoforms. We investigated the Cyr61 gene expression particularly with regard to alternative pre-mRNA splicing and a potential conjunction with the strong hypoxia inducibility of this gene. Methods: Expression profiles were examined in a matched pair analysis of malignant and normal tissues samples of patients with breast or ovarian cancer (RT-PCR). Determined splice variants were cloned for sequence analysis. Hypoxia-induced alterations in alternative splicing patterns of the Cyr61 gene w…

Schlagworte

Cyr61 alternative splicing breast cancer hypoxia ovarian cancer Geburtshilfe und Frauenheilkunde