CareLit Fachartikel

Expression of metalloprotease insulin-degrading enzyme (insulysin) in breast and ovarian cancer tissues

C Yfanti, K Mengele, G Weirich, C Giersig, M Rosner, M Schmitt · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09

Dokument
1073055
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
C Yfanti, K Mengele, G Weirich, C Giersig, M Rosner, M Schmitt
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-12 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0028-1088826

Zusammenfassung

Background. Insulin-degrading enzyme (IDE, insulysin, insulinase; EC 3.4.22.11), a thiol metalloendopeptidase, is involved in intracellular degradation of insulin, thereby inhibiting its translocation and accumulation to the nucleus. Recently, protein expression of IDE has been demonstrated for the first time in the epithelial ducts of normal breast and in breast cancer tissue (Radulescu et al., Int J Oncol 30: 73; 2007). Materials and Methods. Utilizing four different antibodies generated against different epitopes of the IDE molecule, we performed western blot analysis and immunohistochemical staining on sever…

Schlagworte

Insulin-degrading enzyme (IDE) breast cancer normal human tissues ovarian cancer tumor cell lines Geburtshilfe und Frauenheilkunde